The Board is chaired by Peter Yates AM and meets four times a year. Deputy chairs are Jim Carroll and Dr Graham Mitchell, Chief Scientist of Victoria. Other board members include:
| Peter Yates AM, Chair | Chairman, Royal Institution of Australia and Chairman, Faculty of Business and Economics, The University of Melbourne |
| Jim Carroll , Deputy Chair | Chief Executive Officer, MS Australia |
| John Croll | Chief Executive Officer, Sentia Media |
| Dr John Curran | General Manager: Communication, CSIRO |
| Rob Douglas | Chief Operating Officer, ResMed Inc |
| Michael Ellies | Representing APN News and Media Ltd |
| Fiona Fox | Director, UK Science Media Centre |
| Peter Fray | Editor-in-chief, Sydney Morning Herald and Sun-Herald (Fairfax Media) |
| Phil Gardner | Editor, Herald Sun (News Ltd) |
| Brad Hatch | Director of Communications, Fairfax Media |
| Graeme Liebelt | Former Managing Director and CEO, Orica Ltd |
| Melvin Mansell | Editor, The Advertiser, News Ltd |
| Dr Graham Mitchell, Deputy Chair | Chief Scientist, State Govt of Victoria |
| Professor Rob Morrison | Freelance science communicator |
| Paul Ramadge | Editor-in-chief, The Age (Fairfax Media) |
| Professor Rob Saint | Dean of the Faculty of Science, The University of Melbourne |
| The Hon Jay Weatherill | Premier, Govt of South Australia |
| Robyn Williams | Presenter, Science Show, ABC |
| Dr Paul Willis | Director, RiAus |
The NSW Government does not currently have a board member but is represented by Peter Leihn.